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The results of treatment Hodgkin's lymphoma in children

During last decade there have been a lot of changes in strategy of treatment Hodgkin's disease in children. According to very good reaction of chemotherapy ew are trying to find out the stage and subtype of a disease, and the use the less aggressive but very effective therapy which will cure a large number of patients with lwss side effects. It is very well known that secondary malignant tumours are very frequent after successfull therapy of Hodkin' disease. Chemotherapy has the leading tole i treatment this fewer patients. The aim of this report is to give treatment results of children with Hodgkin's disease in Croatia. They were staged and treated in a single institution. Patients and Methods ; At the Department of Hematology and Oncology Children+s Clinic Salata Medical Faculty Zagreb, in the pariod of 1990-2003, 41 children (19 male and 22 female, 2-18 years) with Hodgkin's disease have been treated with combination of cytostatic hterapy (OPPA, OEPA, and COOP) and radiotherapy (involved field radiation) ; 6 vere in stage IA, 13 in stage IIA, 11 in stage IIB, 5 in stage IIIA, 3 in stage IIIB and 3 in stage IVA. Results ; The remission has been achieved in all patiens ; in 5 (12, 2%) relapse appeared due to wich considerably more aggressive cytostatic therapy as well ass radiotherapy were applied ; in 3 (7, 3%) in combination with bone marrow trežansplantation ; 2 (4, 9%) patiens died. 39 (95, 1%) patients are alive in the 1sr or the 2nd remission. Serious side effects were not noticed. Secondary malignancies did not occur in any of patiens. Conclusion ; The results of treatmen are not different from the other European Centres for children's hematology and oncology.

children; Hodgkin's lymphoma; treatment

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