engleski

Angiosarcoma arising in sclerodermatous skin

We report a case of cutaneous angiosarcoma in a 77- year old female patient with systemic sclerosis. The tumor developed around a large teleangiectasia in the left temporal region. Later on, extensive asymptomatic redness and edema with several nodules over the whole left side of the face developed. Since the conservative therapy failed to produce any improvement, a diagnostic skin biopsy was performed. The pathohistological diagnosis was moderatly differentiated angiosarcoma. The patient was terated with a combination of chemotherapy and electron beam irradiation. Despite a notable cutaneous improvement, the control check-up revealed the presence of metastases of the lung and liver. This is the first report of cutaneous angiosarcoma occuring in sclerodermatous skin. The possible pathogenesis of this rare tumorogenic transformation of soft tissue is discussed.

angiosarcoma ; systemic sclerosis ; teleangiectasia

nije evidentirano