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Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits (CROSBI ID 131292)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Campbell, Harry ; Carothers, Andrew D. ; Rudan, Igor ; Hayward, Caroline ; Biloglav, Zrinka ; Barać, Lovorka ; Peričić, Marijana ; Janićijević, Branka ; Smolej-Narančić, Nina ; Polašek, Ozren et al. Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits // Human molecular genetics, 16 (2007), 2; 233-241-x

Podaci o odgovornosti

Campbell, Harry ; Carothers, Andrew D. ; Rudan, Igor ; Hayward, Caroline ; Biloglav, Zrinka ; Barać, Lovorka ; Peričić, Marijana ; Janićijević, Branka ; Smolej-Narančić, Nina ; Polašek, Ozren ; Kolčić, Ivana ; Weber, James L. ; Hastie, Nicholas D. ; Rudan, Pavao ; Wright, Alan F.

engleski

Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits

The dramatic changes in human population structure over the last 200 years have resulted in significant levels of outbreeding, which, in turn, is predicted to lead to increased levels of individual genetic diversity (genome-wide heterozygosity, h). To investigate possible effects of these large demographic changes on global health, we studied the effect of h, measured as relative heterozygosity, hR, on 15 disease-related traits in four groups of individuals with widely differing ancestral histories (ranging from outbred to inbred) from the Dalmatian islands in Croatia. Higher levels of hR, estimated using 1184 STR/indel markers, were found in the outbred group (P < 0.0001) and were associated with lower blood pressure (BP) and total/ LDL cholesterol (P 5 0.01 and 0.01, respectively) after controlling for other factors, with BP showing a strong sex effect (males P > 0.5 and females P 5 0.002). These findings, if replicated, suggest that hR be considered as a genetic risk factor in genetic epidemiological studies on common disease traits. They are consistent with the well-known effects of heterosis (hybrid vigour) described when outcrossing animals and plants. Outbreeding resulting from urbanization and migration from traditional population subgroups may be leading to increasing hR and may have beneficial effects on a range of traits associated with human health and disease. Other traits, such as age at menarche, IQ and lifespan, which have been changing during the decades of urbanization, may also have been influenced by demographic factors.

inbreeding depression; founder population; human hypertension; complex traits; disease; association; loci; components; Drosophila; evolution

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

16 (2)

2007.

233-241-x

objavljeno

0964-6906

Povezanost rada

Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija