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Pregled bibliografske jedinice broj: 296866

Zbornik radova

Autori: Šimić, Goran; Boban, Marina; Šarac, Helena; Grbić, Kristina; Hof, Patrick; Hamann, Christine; Ackl, Nibal; Bader, Benedikt; Danek, Adrian
Naslov: CSF tau proteins in evaluation of patients with suspected dementia
Izvornik: Neurodegenerative Diseases Vol. 4 (Suppl. 1). 8th International Conference AD/PD Alzheimer's and Parkinson's Diseases: Progress and New Perspectives : Abstracts / Fisher, A ; Hanin, I ; Poewe W ; Windisch, M (ur.). - Basel : Karger , 2007. 135-136 (ISBN: 3-8055-8282-7).
ISSN: 1660-2854
Skup: 8th International Conference AD/PD Alzheimer's and Parkinson's Diseases: Progress and New Perspectives
Mjesto i datum: Salzburg, Austrija, 14-18.03.2007.
Ključne riječi: Alzheimer's disease; cerebrospinal fluid; early diagnosis; tau proteins; frontotemporal dementia; vascular dementia; Lewy-body disease; Creutzfeld-Jacob disease
Sažetak:
We tried to evaluate the diagnostic value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early-onset Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD), diffuse Lewy-body disease (DLBD) and Creutzfeld-Jacob disease (CJD). CSF levels were measured using commercially available ELISA kits (t-tau and p-tau199 - BioSource, Camarillo, CA, USA and p-tau181 - Innogenetics, Ghent, Belgium). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. P-tau181 showed best sensitivity and specificity for AD vs DLB (sens. 91%, spec. 94%), t-tau for AD vs VaD (sens. 91%, spec. 95%), while p-tau199 showed low specificity (25-30% when sensitivity was set at 85% or greater). We concluded that total tau and p-tau181 represent useful biological markers for distinguishing AD from other primary causes of dementia, suggesting that CSF examination of tau proteins should become a part of routine diagnostic procedure for patients with suspected dementia.
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
MEDLINE
Web of Science: Science Citation Index Expanded
Scopus
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Upisao u CROSBI: Goran Šimić (gsimic@mef.hr), 2. Svi. 2007. u 15:08 sati
Napomene:
Sažetak rada je tiskan u časopisu Neurodegenerative Diseases 2007 Vol. 4 (Suppl. 1): 135-136. Ovaj časopis se redovito indeksira u Current Contents i Index Medicus/Medline, a sam članak je indeksiran u Science Citation Index expanded.



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