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Pregled bibliografske jedinice broj: 298202

Zbornik radova

Autori: Boban, Marina; Grbić, Kristina; Hof, Patrick; Süssmair, Christine; Ackl, Nibal; Mimica, Ninoslav; Bader, Benedikt; Danek, Adrian; Šimić, Goran
Naslov: Phosphorylated tau proteins in evaluation of patients with suspected dementia
Izvornik: Abstracts of The Second Croatian Congress of Neuroscience ; u: Neurologia Croatica 56 (2007)(S2) / Ivkić, Goran ; Judaš, Miloš ; Klarica, Marin ; Kostović, Ivica ; Šimić, Goran ; Petanjek, Zdravko (ur.). - Zagreb : Denona d.o.o. , 2007. 131-131.
ISSN: 1331-5196
Skup: Croatian Congress of Neuroscience (2 ; 2007)
Mjesto i datum: Zagreb, Hrvatska, 18.-19.05.2007.
Ključne riječi: tau protein; phosphorylation; cerebrospinal fluid; Alzheimer's disease; frontotemporal dementia; vascular dementia; diffuse Lewy-body disease
Sažetak:
One of the major goals of current clinical research in neurodegenerative diseases is early detection. The cerebrospinal fluid (CSF) levels of phosphorylated tau proteins reflect the phosphorylation state of tau in the brain. Our objective was to determine the diagnostic value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early-onset Alzheimer's disease (AD) versus normal controls (NC) and other primary causes of dementia such as frontotemporal dementia (FTD) and vascular dementia (VaD). Patients with probable and possible AD, as well as FTD, VaD, diffuse Lewy-body disease (DLBD) and NC were included in the study. CSF levels were measured using commercially available ELISA kits t-tau and p-tau199 (BioSource, Camarillo, CA, USA) and p-tau181 (Innogenetics, Ghent, Belgium). The median levels of t-tau and p-tau181 proteins studied were significantly elevated in patients with AD compared with other groups. Applied as a single marker, t-tau and p-tau181 reached specificity levels greater than 75% between AD and combined non-AD group when sensitivity was set at 85% or greater. Discrimination between AD and DLBD was maximized using p-tau181, while t-tau maximized separation between AD and VaD. P-tau199 showed low specificity in distinguishing AD from other groups and NC. Our results confirmed that t-tau and p-tau181 may be useful additional markers for distinguishing AD from other primary causes of dementia (such as DLBD and VaD).
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Upisao u CROSBI: Goran Šimić (gsimic@mef.hr), 22. Svi. 2007. u 11:37 sati
Napomene:
Časopis je indeksiran u Neuroscience Citation indexu i EMBASE/Excerpta Medica.



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