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Slow postnatal development of hippocampal CA1 pyramidal neurons suggests prolonged maturation of human declarative memory (CROSBI ID 527959)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | domaća recenzija

Šimić, Goran ; Mladinov, Mihovil ; Rašin, Roko ; Petanjek, Zdravko ; Kostović, Ivica ; Hof, Patrick ; Seress, Laszlo Slow postnatal development of hippocampal CA1 pyramidal neurons suggests prolonged maturation of human declarative memory // Neurologia Croatica / Ivkić, G ; Judaš, M ; Klarica, M et al. (ur.). 2007. str. 49-49

Podaci o odgovornosti

Šimić, Goran ; Mladinov, Mihovil ; Rašin, Roko ; Petanjek, Zdravko ; Kostović, Ivica ; Hof, Patrick ; Seress, Laszlo

engleski

Slow postnatal development of hippocampal CA1 pyramidal neurons suggests prolonged maturation of human declarative memory

The analysis of the postnatal development of the hippocampus has been for the most restricted to animal models. The aim of our study was to examine the postnatal development of pyramidal neurons of the CA1 field of human hippocampus. By using the rapid Golgi technique we analyzed tissue blocks from the left hippocampi of five neurologically normal children and three adults. The quantifications were carried out with the Neurolucida software and revealed that most of the parameters related to spine numbers and dendritic length were increasing from neonate stage to 3.5 years of age. At this age the total dendritic spine number reached about 104% of adult values for basal and about 170% for apical dendrites, while the total dendritic length was about 59% of adult values for basal and 143% for apical dendrites. After 3.5 years of age the mean spine density declined for both apical (because of spine loss) and basal dendrites (mostly due to dendritic lengthening). We concluded that in comparison with data obtained in anthropoid primates, the postnatal development of human hippocampal CA1 pyramidal neurons is prolonged. This protracted maturation, which corresponds with previous descriptions of mossy cell development in the dentate gyrus, indicates very slow development of anatomical substrate of declarative memory in human and may underlie the phenomenon of infantile amnesia.

CA1; hippocampus; declarative memory; Golgi method; development

Časopis je indeksiran u Neuroscience Citation index i EMBASE/Excerpta Medica.

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Podaci o prilogu

49-49.

2007.

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objavljeno

Podaci o matičnoj publikaciji

Neurologia Croatica

Ivkić, G ; Judaš, M ; Klarica, M ; Kostović, I ; Šimić, G ; Petanjek, Z

Zagreb: Denona

0353-8842

Podaci o skupu

Croatian Congress of Neuroscience (2 ; 2007)

poster

18.05.2007-19.05.2007

Zagreb, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

Indeksiranost