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Pregled bibliografske jedinice broj: 298207

Zbornik radova

Autori: Šimić, Goran; Mladinov, Mihovil; Rašin, Roko; Petanjek, Zdravko; Kostović, Ivica; Hof, Patrick; Seress, Laszlo
Naslov: Slow postnatal development of hippocampal CA1 pyramidal neurons suggests prolonged maturation of human declarative memory
Izvornik: Abstracts of the The Second Croatian Congress of Neuroscience : u: Neurologia Croatica Vol. 56 (2007)(S2) / Ivkić, G ; Judaš, M ; Klarica, M ; Kostović, I ; Šimić, G ; Petanjek, Z (ur.). - Zagreb : Denona d.o.o. , 2007. 49-49.
ISSN: 0353-8842
Skup: Croatian Congress of Neuroscience (2 ; 2007)
Mjesto i datum: Zagreb, Hrvatska, 18.-19.05.2007.
Ključne riječi: CA1; hippocampus; declarative memory; Golgi method; development
Sažetak:
The analysis of the postnatal development of the hippocampus has been for the most restricted to animal models. The aim of our study was to examine the postnatal development of pyramidal neurons of the CA1 field of human hippocampus. By using the rapid Golgi technique we analyzed tissue blocks from the left hippocampi of five neurologically normal children and three adults. The quantifications were carried out with the Neurolucida software and revealed that most of the parameters related to spine numbers and dendritic length were increasing from neonate stage to 3.5 years of age. At this age the total dendritic spine number reached about 104% of adult values for basal and about 170% for apical dendrites, while the total dendritic length was about 59% of adult values for basal and 143% for apical dendrites. After 3.5 years of age the mean spine density declined for both apical (because of spine loss) and basal dendrites (mostly due to dendritic lengthening). We concluded that in comparison with data obtained in anthropoid primates, the postnatal development of human hippocampal CA1 pyramidal neurons is prolonged. This protracted maturation, which corresponds with previous descriptions of mossy cell development in the dentate gyrus, indicates very slow development of anatomical substrate of declarative memory in human and may underlie the phenomenon of infantile amnesia.
Rad je citiran u
bazama podataka:
Scopus
Web of Science: Science Citation Index Expanded
Web of Science: Science Citation
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Upisao u CROSBI: Goran Šimić (gsimic@mef.hr), 22. Svi. 2007. u 11:56 sati
Napomene:
Časopis je indeksiran u Neuroscience Citation index i EMBASE/Excerpta Medica.



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