engleski

Are there differences in platelet serotonin and serum cholesterol levels in suicidal and non-suicidal male patients with first psychotic episode?

Suicidal behavior is a major health risk in psychiatric disorders, especially in schizophrenia, and up to 10% patients will commit suicide. The neurobiology of suicide is still unclear. Suicidality has been related to a decreased central serotonergic (5-hydroxytryptamine, 5-HT) function and reduced cholesterol levels. Platelet 5-HT was used as a peripheral marker of the central serotonergic synaptosomes. The hypothesis was that suicidal patients in the first episode of psychosis will have different serum cholesterol and platelet 5-HT concentrations than non-suicidal patients in the first episode of psychosis. The aim of this study was to evaluate serum cholesterol and platelet 5-HT concentrations in suicidal and non-suicidal men in the first episode of psychosis and in healthy male controls. Venous blood samples were collected within 24 hours of admission, and serum cholesterol and platelet 5-HT were determined enzymatically and fluorimetrically. Platelet 5-HT and serum cholesterol concentrations were significantly lower in suicidal than in non-suicidal patients in the first episode of psychosis, and than in healthy controls. Our results suggest that lower concentrations of serum cholesterol and platelet 5-HT in patients with the first episode of psychosis might be useful biological markers of suicidality. References: Marčinko, D., Martinac, M., Karlović, D., Lončar, Č., 2004. Cholesterol serum levels in violent and non-violent young male schizophrenic suicide attempters. Psychiatria Danubina 16, 161-164. Marčinko, D., Martinac, M., Karlović, D., Filipčić, I., Lončar, Č., Pivac, N., Jakovljević, M., 2005. Are there differences in serum cholesterol and cortisol concentrations between violent and non-violent schizophrenic male suicide attempters? Collegium Antropologicum 29, 153-157. Muck-Seler, D., Jakovljević, M., Pivac, N., 1996. Platelet 5-HT concentrations and suicidal behavior in recurrent major depression. Journal of Affective Disorders 39, 73– 80. Pivac N., Jakovljević M., Muck-Seler D., Brzović Z., 1997. Hypothalamic-pituitary-adrenal axis function and platelet serotonin concentrations in depressed patients. Psychiatry Research 73, 123-132. Roy, A., Linnoila, M., 1988. Suicidal behavior, impulsiveness and serotonin. Acta Psychiatria Scandinavica 78, 529– 535. Stahl, S.M., 1985. Platelets as pharmacological models for the receptors and biochemistry of monoaminergic neurons. In: Longenecker (Ed.), The Platelets: Physiology and Pharmacology, pp. 307– 340.

suicidality; the first episode of psychosis; cholesterol; platelet serotonin; men

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