engleski

Inherited prothrombotic risk factors in children with cerebrovascular disorders

Cerebrovascular disorders (CD) are an important cause of mortality and morbidity in children, and an emerging area for clinical research. There is increasing evidence that inherited or acquired prothrombotic disorders may be implicated in the etiology of CD in childhood. We have investigated the prevalence of genetic polymorphisms associated with thrombosis: factor V G1619A (FVL), factor II G20210A (PT), methylenetetrahidropholate reductase C677T (MTHFR), and human platelet antigens (HPA-1, -2, -3 and -5) in 151 children with CD and compared the data with those obtained for the control group (112 children from the same geographical region). Children with CD were classified into 5 groups according to diagnosis based on clinical symptoms, neurological examination, computed tomography and magnetic resonance imaging of the brain: children with arterial ischemic stroke (AIS ; n=36), perinatal arterial ischemic stroke (PAIS ; n=26), transient ischemic attack (TIA ; n=36), migraine (n=35) and intracranial hemorrhage (ICH ; n=18). Similar genotype distributions of all studied polymorphisms were found only between children with ICH and controls. Statistically significant differences between controls and other groups of children with CD were observed for at least one polymorphism: for FVL in children with AIS and TIA (p=0.048), for MTHFR in children with AIS (p=0.036), PAIS (p=0.034) and migraine (p=0.037), for HPA-2 and -5 (p=0.037) in children with TIA. Furthermore, higher frequencies of the HPA-3a allele in children with AIS were found to be statistically significant (p=0.027), as compared to the control group. Obtained results indicate that different polymorphisms are implicated in the etiology of CD in childhood.

inherited prothrombotic risk factors; stroke; TIA; migrein

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