engleski

Oral Candida species susceptibility to antimycotics in patients receiving head and neck radiotherapy

Objectives: Treatment of cancer is associated with shot and long-term side effects. Oral side effects include oral candidal infection. This infection cause discomfort and is a potential source of systemic infection. The aim of his study was to determine the current status of susceptibility to antimycotic drugs among hospitalized patients on Oncology unit in Clinical hospital Rijeka. Methods: Oral swabs were collected from 32 hospitalized patients receiving head and neck radiotherapy treatmen for malignant disease. Yeasts isolates were evaluated for their susceptibilities to two antimycotic drugs (miconazole and nystatin) by disk diffusion method (NeoSensitabs, Taalstrup, Denmark) on Mueller-Hinton agar. Results: At the time of sampling, 14 (43, 75%) patients were found to be colonized with yeasts. All the isolates were Candida albicans. Antifungal susceptibility patterns showed that 100% of isolates were susceptible to nystatin with mean inhibiton zone 20 &plusmn ; ; ; ; ; ; ; ; 1, 96mm (isolates with inhibition zone > 15 mm were susceptible). In contrast, 71% of isolates were susceptible to miconazole with mean inhibition zone 21 &plusmn ; ; ; ; ; ; ; ; 2, 98 mm while 29 % showed intermediar resistance (susceptible = inhibition zone >20 mm, intermediar resistance = inhibition zone 12-19 mm). Conclusion: Our results showed that local nystatin therapy is effective in treatment oral candidal infection in patients receiving head and neck radiotherapy.

Candida species; susceptibility; antimycotics; head and neck radiotherapy

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