engleski

Determination of pKa values of active pharmaceutical ingredients

The dissociation constant is an important physicochemical parameter of a substance, and knowledge of it is of fundamental importance in a wide range of applications and research areas. We present a critical review of published methods and approaches for the determination of dissociation constants, with a special emphasis on the pKa values of active pharmaceutical ingredients.

active pharmaceutical ingredient ; capillary electrophoresis ; dissociation constant ; liquid chromatography ; potentiometry ; spectrophotometry

nije evidentirano