Rapid splenic contraction and heart rate increase at the onset of apnea in human (CROSBI ID 529941)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Baković, Darija ; Dujić, Željko ; Palada, Ivan ; Obad, Ante ; Ivančev, Vladimir ; Shoemaker, Kevin J. ; Valić, Zoran
engleski
Rapid splenic contraction and heart rate increase at the onset of apnea in human
We previously observed that the spleen contracts during maximal apnea and stays contracted for prolonged period after series of apneas. The role of central mechanisms in the initial splenic contraction and cardiovascular responses during apnea is unknown. Now, we investigated changes occurring during short apneas lasting 15 s during which arterial O2 and CO2 levels are unchanged. We studied changes in splenic size and blood flow, as well as central and peripheral cardiovascular parameters before, during and after a single apnea both with and without forehead cold stimulation to isolate the effect of the diving response from the apnea. Splenic artery diameter and blood velocity were not significantly changed during apnea. Spleen volume was reduced by about 20% as early as 3 seconds after the start of apnea and was quickly recovered after cessation of the attempt. Heart rate increased early during the apnea, simultaneously with spleen volume change to compensate for reductions in stroke volume and arterial pressure. Heart rate recovered towards baseline levels later in each apnea as arterial pressure was restored in concert with a rise in peripheral resistance. Splenic contraction and cardiovascular changes were not influenced by facial cold stimulation. Results indicate that sympathetic nerve activation to spleen and heart occurs during initial stage of the diving.
spleen; apnea; diving response; cardiovascular responses
Zbornik tiskan u časopisu The FASEB journal 21(2007) u jednom od 3 sveščića izašlih u travnju ; ISSN 0892-6638.
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Podaci o prilogu
A1359-A1359-x.
2007.
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objavljeno
Podaci o matičnoj publikaciji
FASEB journal
0892-6638
Podaci o skupu
Experimental Biology 2007
poster
28.04.2007-02.05.2007
Sjedinjene Američke Države