engleski

Sinergistic effect of anti-LPS monoclonal antibody and ceftazidime against Klebsiella pneumoniae infection

The aim of this work was to determine the existence of the synergy between effects of anti-LPS antibodies and ceftazidime in a mouse model of Klebsiella pneumoniae infection. In our experiments we used BALB/CN mice separated in two groups each containing 6 animals. One group received saline (unprotected) and other 1 mg per animal of anti-LPS antibodies (protected) 4 hours prior to the infection. Animals were infected intranasally with 260 CFU of Klebsiella pneumoniae. Twenty-four hours after the infection animals received 80 mg/kg ceftazidime intraperitonelly. CONCLUSIONS: This study shows that combination of monoclonal antibodies and antibiotic treatment enhances the survival of lethally infected animals. In the protected group the survival rate was 66 % while in the unprotected group treated only with a single dose of ceftazidime the survival was 33%.

Klebsiella pneumoniae; anti-LPS immunity; antibiotic

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