engleski

Distribution of Human papillomavirus (HPV) types 6/11, 16, 18, 31, 33, 45, 52 and 58 among Croatian women

The infection with Human papillomavirus (HPV) is the central cause of cervical cancer. There are at least 15 high-risk (HR) HPV types that are significantly associated with progression of cervical intraepithelial neoplasia to cervical cancer. The purpose of this study was to evaluate the prevalence of worldwide most common HPV types according to cervical diagnosis and women’ s age. HPV DNA was detected by consensus primers directed polymerase chain reaction (PCR). Type-specific primers were used to determine low-risk HPV types 6/11 and HR HPV types 16, 18, 31, 33, 45, 52 and 58. Out of 2, 136 cervical specimens, 1, 255 (58.8%) were positive for HPV of which 64.5% were typed. The most prevalent type, including both single and multiple infections, was HPV 16 with the prevalence of 15.9%, followed in decreasing order by HPV types 31, 6/11, 33, 18, 52, 45 and 58 with the prevalence of 8.7%, 7.1%, 4.5%, 3.8%, 2.3%, 1.2% and 1.1%, respectively. The significant increase of frequency from low-grade squamous intraepithelial lesions (LSIL) to high-grade squamous intraepithelial lesions (HSIL) was observed for HR HPV types 16, 18, 31 and 33 but not 45, 52 and 58. The frequency of unknown HPV types was almost the same in cervical specimens of women with LSIL and those with HSIL, 19.8% and 21.1%, respectively. The prevalence of HPV infection rate decreased significantly with patient age from 68.5% (age group 12 to 24 years) to 38.8% (age group 45 to 54 years). But, in women aged 55 or older the overall prevalence increased to 56.6%. Our results indicate that HPV positive women should be typed for at least HR HPV types 16, 18, 31 and 33, especially in case of older women with high-grade cervical lesions.

Human papillomaviruses (HPV)

nije evidentirano