engleski

Characteristics and Significance of Microbial Biofilm Formation

Biofilm is a microbially derived sessile community characterized by cells that are attached to an abiotic or living surface and embedded in a matrix of extracellular polymeric substances that they have produced. This polymicrobic community has an altered phenotype and it is physiologically different from planktonic microorganisms. Epidemiological studies have shown that biofilm formation is associated with more than 60% of all human infections. Since microorganisms growing in a biofilm are highly resistant to antimicrobial agents and host’ s immune system, it is necessary to employ effective methods for the prevention or control of biofilm formation. Formation and persistance of a biofilm is a complex and dynamic process that needs to be studied as better understanding of biofilm characteristics will enable the development of new therapeutic strategies.

Biofilm; infectious diseases; pathogenesis

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