engleski

Ethiopathogenesis of bronchopulmonary carcinoma

The most frequent cause of death in males in Croatia is the bronchopulmonary carcinoma. In this study we analyzed dermatoglyphics in 416 male and 135 female patients suffering from lung cancer, and 200 male and 200 female healthy adults. The quantitative dermatoglyphic analysis on 18 variables shows classification results of canonical discrimination: between patients suffering from lung cancer and control groups in males 79.87% and in females 79.70% cases are grouped correctly. The qualitative analysis of dermatogliphic patterns between different types of lung cancer also show existing differences whilst using Hiernaux Dg biological distances. Despite the biological heterogenity of these tumours, there is proof of their common determination compared to the control group. This suggests a polygenetic origin of these diseases and their possible genetic common alternation. Biological differences found among different types of carcinoma indicate that although these tumours have common basis, their biological distances create a basis for a conclusion that different pathways of genetic alternation represent the source of diverse pathophysiolology of these disease. Our research findings are confirmed by other methods as well. for example, by methods of molecular biology where different types of genetic markers in different types of carcinoma could be detected.

bronchopulmonary carcinoma; anthropology; population genetics

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