Chromosome studies in patients with defective reproductive success (CROSBI ID 135683)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Radojčić Badovinac, Anđelka ; Buretić-Tomljanović, Alena ; Starčević, Nada ; Kapović, Miljenko ; Vlastelić, Ivan ; Randić, Ljiljana
engleski
Chromosome studies in patients with defective reproductive success
Problem: The objective of this study was to evaluate the contribution of chromosomal anomalies to decreased fertility in humans. Method of study: In order to investigate the aetiology of infertility in our population and to assess the karyotype in a group of infertile couples and individuals with fertility problems, 782 persons (259 couples, 158 male and 106 female) with different clinical diagnoses of sterility and infertility were analysed cytogenetically. Results: The overall frequency of major chromosomal aberration was 13.1% (103/783), which suggests that fertility or sterility problems in this population are due to chromosomal aberrations. Couples experiencing repeated spontaneous abortions, having malformed children or having sterility problems had chromosomal abnormalities in 18.0% (47/259 couples) of the population studied, and constituted chromosomal disorders occured in couples seeking IVF and ICSI with prevalence of 22.2% (8/38 couples), especially minor mosaicism of sex chromosomes in the female partners. The prevalence of chromosome abnormalities in infertile men was 17.7% (28/158), and in subfertile females, it was 26.4% (28/106). Conclusions: These results could indicate an increased tendency to mitotic sex chromosome non-disjuction in humans.
chromosomal aberration ; fertility ; spontaneous abortions ; sterility
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Podaci o izdanju
44 (5)
2000.
279-283
objavljeno
1600-0897
10.1111/j.8755-8920.2000.440505.x