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Methylentetrahydrofolate reductase polymorphism and susceptibility to prostate cancer (CROSBI ID 533096)

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Šimundić, Ana-Maria ; Reljić, Ante ; Nikolac, Nora ; Justinić, Danijel ; Kraus, Ognjen Methylentetrahydrofolate reductase polymorphism and susceptibility to prostate cancer // European Urology Meetings. 2007. str. 58-x

Podaci o odgovornosti

Šimundić, Ana-Maria ; Reljić, Ante ; Nikolac, Nora ; Justinić, Danijel ; Kraus, Ognjen

engleski

Methylentetrahydrofolate reductase polymorphism and susceptibility to prostate cancer

Introduction & Objectives: Methylentetrahydrofolate reductase (MTHFR) is the most important enzyme involved in DNA methylation process and converts 5, 10-methyltetrahydrofolate to 5-methyltetrahydrofolate. The C677T polymorphism of the MTHFR gene is associated with 70% lower enzyme activity and hypomethylation. many studies investigated the role of MTHFR polymorphism in cancer susceptibility and though most authors report lower frequency of mutated T allele in cancer patients, results are still inconclusive. The aim of this studa was to asses the frequency distribution of mutated T allele in the patients with prostatic cancer (PC) and benign prostatic hyperplasia (BPH). material & methods: The case control study comprised of 45 patients with BPH and 95 patients with prostatic cancer. For the patients with carcinoma, Gleason score was determined as an index of degree of malignancy. PCR-RFLP method was used to determine MTHFR C677T polymorphism. Results: Genotypes in both groups were in Hardy-Weinberg equilibrium. Proportions of genotypes in PC group were C/C=0.40, C/T=0.51 and T/T=0.09 and in the BPH group C/C=0.47, C/T=0.42 and T/T=0.11. There was no statistically significant difference in genotype distribution between groups (P=0.6558). Odds ratio and 95% confidence interval for the C/T genotype was 1.3961(0.658-2.963) and for the T/T genotype 0.9947(0.295-3-357). Proportions in the group of patients with prostatic cancer of lower malignancy (Gleason score 4-6) were C/C=0.39, C/T=0.47 and T/T=0.14 ; and in the group with more malignant prostatic cancer (Gleason score 7-9) C/C=0.40, C/T=0.53 and T/T=0.07. Proportions between groups with higher and lower malignancy were not different (P=0.8693). Conclusions: results of our research didn't provide any evidence for the association of MTHFR C677T polymorphism with prostate cancer risk.

MTHFR; prostate cancer

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Podaci o prilogu

58-x.

2007.

objavljeno

Podaci o matičnoj publikaciji

European Urology Meetings

Podaci o skupu

EAU 7th Central European Meeting

poster

26.09.2007-27.09.2007

Zagreb, Hrvatska

Povezanost rada

Kliničke medicinske znanosti