engleski

Biocard 41: E-cadherin

This gene can play a major role in malignant cell transformation, and especially in tumor development and progression. Most tumors (including melanoma) have abnormal cellular architecture, and loss of tissue integrity can lead to local invasion. Thus, loss of function of E-cadherin tumor suppressor protein correlates with increased invasiveness and metastasis of tumors, resulting in it being referred to as the "suppressor of invasion" gene.

melanoma; E-cadherin

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