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Pregled bibliografske jedinice broj: 322915

Zbornik radova

Autori: Šarac, Helena; Hajnšek, Sanja; Bašić, Silvio; Henigsberg, Neven; Radoš, Marko; Šimić, Goran
Naslov: Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein
Izvornik: European Journal of NeurologyBrussels, Belgium : EFNS , 2007. 58-58.
Dio CC časopisa: DA
ISSN: 1351-5101
Skup: 11th Congress of the European Federation of Neurological Societies (EFNS)
Mjesto i datum: Brisel, Belgija, 25-28.08.2007.
Ključne riječi: sporadic Creutzfeldt-Jakob disease; magnetic resonance spectroscopy; tau proteins; cerebrospinal fluid
Sažetak:
Over the last several years, it has became clear that electroencephalogram (EEG), magnetic resonance imaging (MRI) and measurement of cerebrospinal fluid (CSF) 14-3-3 proteins are of limited potential in the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD). However, some recent reports suggested that magnetic resonance spectroscopy (MRS) and measurement of CSF total tau (t-tau) and phospho-tau (p-tau) proteins could be more useful for ante mortem diagnosis of sCJD. We therefore included these two methods in the diagnostic procedure of a patient with clinically suspected (and later autopsy-proven) sCJD. In contrast to non-specific EEG and MRI findings and negative 14-3-3 proteins in CSF, MRS revealed metabolic alterations in regions of the brain that looked apparently normal on MRI, while tau proteins profiles showed increased levels of both non-phosphorylated and some phosphorylated tau isoforms. We concluded that a combination of serial functional MRI together with MRS and measurement of CSF tau proteins in patients with rapidly progressive dementia syndrome helps to obtain a more reliable early diagnosis of sCJD.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Tiskani medij: da
Upisao u CROSBI: Goran Šimić (gsimic@mef.hr), 21. Vel. 2008. u 11:39 sati



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