crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 322923

Zbornik radova

Autori: Boban, Marina; Grbić, Kristina; Hof R. Patrick; Süßmair, Christine; Ackl, Nibal; Bader, Benedikt; Danek, Adrian; Šimić, Goran
Naslov: CSF levels of total tau, tau protein phosphorylated at threonine 181 and serine 199 as predictors of Alzheimer's disease in patients with mild cognitive impairment
Izvornik: European Journal of NeurologyBrussels, Belgium : EFNS , 2007. 95-95.
Dio CC časopisa: DA
ISSN: 1351-5101
Skup: 11th Congress of the European Federation of Neurological Societies
Mjesto i datum: Brisel, Belgija, 25-28.08.2007.
Ključne riječi: Alzheimer's disease; cerebrospinal fluid; early diagnosis; ELISA; mild cognitive impairment; phoshorylated epitopes; tau proteins
Sažetak:
Patients with mild cognitive impairment (MCI), especially those with the amnestic type of MCI, have an elevated risk for development of Alzheimer’ s disease (AD). Since treatment for AD is likely to have the best efficacy in the early or even preclinical phase of the disease, it is necessary to find biomarkers which would help to identify incipient AD in MCI cohorts. Our objective was to investigate the value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau-181) and at serine 199 (p-tau-199) for the prediction of AD among patients with MCI. Patients with a clinical diagnosis of MCI-amnestic type as well as healthy controls were included. CSF levels of t-tau, p-tau-181 and p-tau-199 were measured using commercially available ELISA kits (Innogenetics, Ghent, Belgium ; Biosource International, Camarillo, CA, USA). After two years of follow-up MCI patients were divided in two groups: “ stable MCI” or “ MCI converters” (those who progressed to AD). Our preliminary results showed that CSF levels of t-tau and p-tau-181 proteins were significantly elevated in MCI converters compared to stable MCI patients and healthy controls. We therefore concluded that CSF levels of t-tau and p-tau-181 could be valuable markers of early AD in patients with MCI and, consequently, for early selection of patients for treatment.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Tiskani medij: da
Upisao u CROSBI: Goran Šimić (gsimic@mef.hr), 21. Vel. 2008. u 12:19 sati



Verzija za printanje   za tiskati


upomoc
foot_4