engleski

Synthesis and spectroscopic properties of furyl-phenyl-acrylates and naphthofurans and their interaction with ct-DNA

A series of novel substituted derivatives, related to furyl-phenyl-acrylates and naphthofurans, has been synthesized and characterized by UV/Vis and fluorescence spectroscopy. Acyclic compounds can undergo phothochemical dehydrocyclization by visible light irradiation in order to obtain their cyclic derivatives. The interactions of prepared compounds with calf thymus DNA was investigated by means of electronic absorption and fluorescence spectra. It is intriquing that addition of ct-DNA induced fluorescence increase of acyclic derivatives, exactly the opposite than strong fluorescence quenching observed for cyclic derivatives 10 and 12.

heterocycles ; photochemistry ; UV/Vis spectroscopy ; fluorescence spectroscopy ; DNA

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