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Evaluation of a high-throughput magnetic-particle triclosan immunoassay and results of their application for continental waters monitoring in the Mediterranean area

Triclosan is a microcide, registered in the EPA as a pesticide, and has been incorporated into a wide variety of household and healthcare products. A magnetic particle-based immunoassay to determine triclosan was evaluated against a gas chromatography-mass spectrometry (GC-MS)method for the determination of triclosan and its metabolite, methyl triclosan in tap water, river water, and wastewater in an environmental monitoring study carried out in Catalonia (Spain). Water samples were prepared to contain 25% methanol and analyzed directly without any sample extraction or preconcentration by the triclosan ELISA, and after solid phase extraction measured by GC-MS. Good agreement was obtained between chromatographic results and the immunoassay for samples which triclosan content was lower than 5 ppb. This study is of great interest given the frequency with which triclosan and methyl triclosan were found in natural samples of Spanish rivers, as well as the high concentrations found in river waters and wastewater.

Triclosan; Methyl triclosan; Water; Immunoassay

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