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The effect of selenium pre-treatment on selenium content and lipid peroxidation in cadmium exposed suckling rats (CROSBI ID 535066)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Lazarus, Maja ; Orct, Tatjana ; Jurasović, Jasna ; Blanuša, Maja The effect of selenium pre-treatment on selenium content and lipid peroxidation in cadmium exposed suckling rats // Book of Abstacts, 4th International Conference on Metals and Genetics ICMG 2008. Pariz, 2008. str. 99-x

Podaci o odgovornosti

Lazarus, Maja ; Orct, Tatjana ; Jurasović, Jasna ; Blanuša, Maja

engleski

The effect of selenium pre-treatment on selenium content and lipid peroxidation in cadmium exposed suckling rats

Higher and prolonged gastrointestinal absorption of cadmium (Cd) in newborns compared to adults, and its nature to accumulate in the critical tissues gives importance to early postnatal studies specially in conditions of increased environmental exposure to Cd. Developing brain has been recognized as particularly vulnerable to toxic effects of Cd. Cadmium can be transported through immature blood-brain barrier (BBB) and cause oxidative destruction of membrane polyunsaturated fatty acids (i.e. lipid peroxidation, LPO) in brain and the other tissues as well. Selenium (Se) has known antioxidative potential being part of free radical scavenging enzyme glutathione peroxidase (GSH-Px). In this study we investigated levels of LPO and Se in Cd exposed suckling pups orally pre-treated with Se. Our earlier results evidenced the lower tissue Cd levels in Se supplemented suckling pups. Six days old suckling Wistar rats were pre-treated with Se (as Na2SeO3) and after four days, rats were orally and concurrently treated for another five days with Cd (as CdCl2xH2O) and Se in equimolar amounts (8 μ mol/kg b.w./day, each). Lipid peroxidation in kidney, liver and brain homogenates was quantified using the thiobarbituric acid reactive substances (TBARS) assay. Results confirmed significant decrease in tissue Cd levels in Se supplemented suckling rats (Cd+Se-treated group) in comparison to Cd exposed rats (Cd only). The analysis of Se content in different pups´ tissues indicated significant effect of oral treatment with Se (Se only) on the Se concentration in blood, kidney, liver and brain. In the presence of concurrent Cd exposure (Cd+Se group) Se concentration in blood, brain and kidney was significantly lower when compared to Se-treated animals (Se only). There was no significant increase in LPO in Cd treated group compared to control. However, pretreatment with Se (Se+Cd group) caused statistically significant change in LPO level in liver and brain in comparison to Cd exposed group. These results indicate some Cd/Se interaction at the investigated sites.

cadmium exposure; lipid peroxidation; selenium pre-treatment; suckling rats

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Podaci o prilogu

99-x.

2008.

objavljeno

Podaci o matičnoj publikaciji

Book of Abstacts, 4th International Conference on Metals and Genetics ICMG 2008

Pariz:

Podaci o skupu

4th International Conference on Metals and Genetics ICMG 2008

poster

21.07.2008-24.07.2008

Pariz, Francuska

Povezanost rada

Kemija, Javno zdravstvo i zdravstvena zaštita