Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets (CROSBI ID 138897)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Domitrović, Robert ; Tota, Marin ; Milin, Čedomila Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets // Nutrition research, 28 (2008), 4; 263-269. doi: 10.1016/j.nutres.2008.01.007

Podaci o odgovornosti

Domitrović, Robert ; Tota, Marin ; Milin, Čedomila

engleski

Differential effect of high dietary iron on alpha-tocopherol and retinol levels in the liver and serum of mice fed olive oil– and corn oil– enriched diets

The influence of dietary fats on cellular alpha-tocopherol and retinol uptake in iron overload is poorly understood. The aim of this study was to investigate the effect of a high-iron diet on the retinol and alpha-tocopherol levels in mice fed olive oil– and corn oil– enriched diets. Mice were fed for 3 weeks a standard mouse chow (the control group) and diets enriched with 5% by weight of corn oil or olive oil. Diets of the mice fed corn oil and olive oil were additionally supplemented with 1% by weight carbonyl iron. Both dietary oils and iron increased the liver iron uptake. High-iron feeding induced oxidative stress in mice liver, measured as a thiobarbituric acid-reactive substance level. Both fats and iron induced changes in the liver fatty acid composition. Liver retinol and alpha-tocopherol stores increased with iron supplementation in the olive oil– enriched diet, with a simultaneous decrease in serum. The results suggest that the influx of alpha-tocopherol and retinol from serum to the liver is induced by high dietary iron. This redistribution appears to be stronger for retinol than for alpha-tocopherol and is also higher in mice fed olive oil than in mice fed corn oil, suggesting that the composition of dietary lipids is important in the treatment of high-iron tissue conditions. In conclusion, the results of this study suggest that the increase of hepatic alpha-tocopherol and retinol levels in the olive oil– based diet is a dietary-dependent responsive mechanism that probably is not primarily related to an increased risk of oxidative damage induced by high-iron intake.

olive oil; corn oil; diet; iron; retinol; alpha-tocopherol; TBARS; mice

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

28 (4)

2008.

263-269

objavljeno

0271-5317

10.1016/j.nutres.2008.01.007

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost