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Uric acid and inflammatory activity in cardiovascular diseases

There is an elevated activity of xanthine oxsidase (XO) in cardiovascular diseases (CVD), wich increases the serum concentration of uric acid (UA) and also the formation of free radicals. The objective of this paper was to compare serum values of a known inflammatory marker - high-sensitivity C-reactive protein (hs-CRP), and UA. Demographic data, CVD etiology, CV risk factors and values of hs-CRP and UA were analyzed within a group of 23 female patients. Results: Patients´ average age was 71.8+/-9.6 years. 18 (78.3%)patients had hypertension, 12 (52.2%) had diabetes, while 13 (56.5%) patients had dislipidaemia. None of the patients were smokers. 9 (39.1%) patients suffered from angina pectoris or previous myocardial revascularization, 6 (26.1%) patients had ishemic cardiomyopathy. Average hs-CRP value was 2.90+/-2.11 mg/L (range 0.5-8.31 mg/L), and UA was 394.4+/-102.1 umol/L (range 241-699 umol/L). The patients were divided into three groups according to the hs-CRP values. The first group (n=5) was comprised of patients with hs-CRP level of 0.1-1.0 mg/L, the second group (n=7) were patients with values of 1.1-3.0 mg/L, and the third group (n=11) were patients with values > 3.0 mg/L. The average hs-CRP value in the first group was 0.668+/-0.190 mg/L, 1.884+/-0.319 mg/L in the second, and 4.562+/-1.866 mg/L in the third group. Increase in the level of hs-CRP was accompanied by the increase of the UA level. The first group had the lowest average UA level (314.2+/-53.3 umol/L), in the second group it was higher (386.0+/-72.3 umol/L), and the highest level was in the third group (436.2+/-116.1 umol/L). Conclusion: Inflammation follows all stages of atherothrombosis. Circulating inflammatory marker hs-CRP is the predictor of myocardial infarction, stroke and sudden death. Congestive heart failure is also accompained with activation of the inflammatory process, and the recovery of the left ventricle function can reduce circulating inflammatory markers. Our preliminary results demonstrate that, in CVD, hyperuricemia can also be considered a marker of elevated inflammatory activity and CV risk.

uric acid; C-reactive protein; cardiovascular diseases

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