engleski

CHOLESTEROL LEVEL IN ALZHEIMER’ S DEMENTIA

The aim of study was to evaluate the levels of cholesterol in patients with Alzheimer's dementia (AD) and vascular dementia (VaD). Sixty-six patients with dementia were enrolled in this study. AD was diagnosed in 43 and VD in 23 patients. In a group of 43 patients (22 males and 21 females) with AD, mean age 72, 79 years (standard deviation /SD/=8, 19 years), and in a group of 23 patients with VaD, mean age 77, 43 (SD=7, 58) plasma values of cholesterol were analyzed. In AD group 18 patients had normal, while 25 had elevated plasma cholesterol levels, while in VaD group 12 patients had elevated and 11 had normal plasma cholesterol levels. Mean plasma level of total cholesterol was 5, 39 (SD=1, 05), LDL cholesterol was 3, 33 (SD= 0, 95), and HDL cholesterol was 1, 41 (SD= 0, 34) in patients with AD. In patients with VaD mean plasma level of total cholesterol was 5, 78 (SD=1, 06), LDL cholesterol was 3, 72 (SD=0, 85) and HDL cholesterol was 1, 44 (SD=0, 57). The levels of cholesterol, LDL cholesterol, HDL cholesterol were higher in group of patients with VaD, but the difference did not receive statistical significance. Our data show that patients with AD have elevated plasma levels of cholesterol. Results of this study support the idea that cholesterol could have some influence on etiology, onset and progression of AD, as well as on pathogenesis of VaD.

cholesterol; Alzheimer's dementia; vascular dementia

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