CSF tau proteins in evaluation of patients with suspected dementia (CROSBI ID 35723)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Šimić, Goran ; Boban, Marina ; Šarac, Helena ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian
engleski
CSF tau proteins in evaluation of patients with suspected dementia
Using commercially available ELISA kits, we evaluated the diagnostic value of CSF total tau protein (t-tau), tau phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD) and dementia with Lewy-bodies (DLB). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. Discrimination between AD and DLB was maximized by using p-tau181 with a sensitivity of 91% and a specificity of 94%, whereas t-tau was optimal to separate AD from VaD with a sensitivity of 91% and specificity of 95%. P-tau199 showed low specificity of 20-30% in distinguishing AD from other groups when sensitivity was set at 85% or greater. We concluded that p-tau181 and t-tau represent useful biological markers for differentiating early AD from other causes of dementia.
cerebrospinal fluid, dementia, differential diagnosis, early diagnosis, phosphorylated epitopes, tau proteins, ELISA
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nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
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Podaci o prilogu
239-243.
objavljeno
Podaci o knjizi
New trends in Alzheimer and Parkinson related disorders: ADPD 2007 (Current Contents)
Hanin, I ; Windisch M ; Poewe, W ; Fisher, A
Bolonja: Medimond International Proceedings
2007.
978-88-7587-405-6