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CSF tau proteins in evaluation of patients with suspected dementia (CROSBI ID 35723)

Prilog u knjizi | izvorni znanstveni rad

Šimić, Goran ; Boban, Marina ; Šarac, Helena ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian CSF tau proteins in evaluation of patients with suspected dementia // New trends in Alzheimer and Parkinson related disorders: ADPD 2007 (Current Contents) / Hanin, I ; Windisch M ; Poewe, W et al. (ur.). Bolonja: Medimond International Proceedings, 2007. str. 239-243

Podaci o odgovornosti

Šimić, Goran ; Boban, Marina ; Šarac, Helena ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian

engleski

CSF tau proteins in evaluation of patients with suspected dementia

Using commercially available ELISA kits, we evaluated the diagnostic value of CSF total tau protein (t-tau), tau phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD) and dementia with Lewy-bodies (DLB). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. Discrimination between AD and DLB was maximized by using p-tau181 with a sensitivity of 91% and a specificity of 94%, whereas t-tau was optimal to separate AD from VaD with a sensitivity of 91% and specificity of 95%. P-tau199 showed low specificity of 20-30% in distinguishing AD from other groups when sensitivity was set at 85% or greater. We concluded that p-tau181 and t-tau represent useful biological markers for differentiating early AD from other causes of dementia.

cerebrospinal fluid, dementia, differential diagnosis, early diagnosis, phosphorylated epitopes, tau proteins, ELISA

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Podaci o prilogu

239-243.

objavljeno

Podaci o knjizi

New trends in Alzheimer and Parkinson related disorders: ADPD 2007 (Current Contents)

Hanin, I ; Windisch M ; Poewe, W ; Fisher, A

Bolonja: Medimond International Proceedings

2007.

978-88-7587-405-6

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija