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Pregled bibliografske jedinice broj: 337503

Poglavlje/Rad u knjizi

Autori: Šimić, Goran; Boban, Marina; Šarac, Helena; Grbić, Kristina; Hof, Patrick; Hamann, Christine; Ackl, Nibal; Bader, Benedikt; Danek, Adrian
Naslov: CSF tau proteins in evaluation of patients with suspected dementia
Knjiga: New trends in Alzheimer and Parkinson related disorders: ADPD 2007 (Current Contents)
Urednik/ci: Hanin, I ; Windisch M ; Poewe, W ; Fisher, A
Izdavač: Medimond S.r.l.
Grad: Bologna
Godina: 2007
Serija: Medimond International Proceedings
Raspon stranica:: 239-243
Ukupni broj stranica u knjizi:: 5
ISBN: 978-88-7587-405-6
Ključne riječi: cerebrospinal fluid, dementia, differential diagnosis, early diagnosis, phosphorylated epitopes, tau proteins, ELISA
Sažetak:
Using commercially available ELISA kits, we evaluated the diagnostic value of CSF total tau protein (t-tau), tau phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD) and dementia with Lewy-bodies (DLB). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. Discrimination between AD and DLB was maximized by using p-tau181 with a sensitivity of 91% and a specificity of 94%, whereas t-tau was optimal to separate AD from VaD with a sensitivity of 91% and specificity of 95%. P-tau199 showed low specificity of 20-30% in distinguishing AD from other groups when sensitivity was set at 85% or greater. We concluded that p-tau181 and t-tau represent useful biological markers for differentiating early AD from other causes of dementia.
Projekt / tema: 108-1081870-1942
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti,Psihologija
Upisao u CROSBI: gsimic@mef.hr (gsimic@mef.hr), 5. Svi. 2008. u 13:50 sati



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