engleski

REGULATORY T CELLS (Tregs) INTERPLAY WITH NKT CELLS IN CONTROL OF TUMOR GROWTH

Regulatory T cells (Tregs) represent a subpopulation of suppressor T cells that mediate immune tolerance by suppressing autoreactive T cells. Tregs control tumor expansion at the priming, as well as at the effector’ s phase of T-ell immune responses. Immune system's capacity to distinguish between innocuous and harmful foreign antigens is controlled by mechanisms of central and peripheral tolerance. Mechanisms of peripheral tolerance involve induction of cell death or the development of a non-responsive state (anergy) of T cells. Regulatory T (Treg) cells have active suppression mode and may induce peripheral tolerance. These immunoregulatory mechanisms of Treg cells are the subject of intensive investigation. Dendritic cells (DCs) maturation and/or activation are important in the induction of peripheral tolerance and may control peripheral tolerance inducing the differentiation of Treg cells. In this study, we attempted to analyse the characteristics of human regulatory T and NKT cells, using a flow cytometric technique (FACSCalibur) for detecting phenotype profiles of isolating human peripheral blood lymphocytes (PBL) of patients with lung carcinoma, comparing to healthy volunteers. Our data indicate that the patients with lung carcinoma have significantly increased the percentage of Tregs and NKT cells, which may interplay with the number and function of dendritic cells.

Tregs; colorectal carcinoma; peropheral tolerance; innate immunity

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