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Differential expression of the perforin in human peripheral blood lymphocytes of patients with lung carcinoma (CROSBI ID 536503)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Marija Petković, Ines Mrakovčić-Šutić, Ingrid Belac-Lovasić, Franjo Lovasić Differential expression of the perforin in human peripheral blood lymphocytes of patients with lung carcinoma // 5th Central European Oncology Congress. 2007

Podaci o odgovornosti

Marija Petković, Ines Mrakovčić-Šutić, Ingrid Belac-Lovasić, Franjo Lovasić

engleski

Differential expression of the perforin in human peripheral blood lymphocytes of patients with lung carcinoma

Current data shown that the development of lung carcinoma is a multistep process that involves a successive loss of genes, environmental factors and behavioral habits. The aim of this study was to examine alteration of cell mediate immunity and cytolytic molecule perforin in different lymphocyte subpopulation in peripheral blood of lung cancer patients. Venous blood samples were taken and peripheral blood leukocytes (PBL) were isolated. Phenotype of lymphocytes and perforin expression were analyzed using intracellular and surface immunofluoresecncy and flow cytometric analysis (FACSCalibur). Statistical analysis was done in computer program Statistica 7.1 (StatSoft, Inc., Tulsa, OK, USA). Graphs and tables were done in computer program Microsoft Excel. The results demonstrated that 10-15% of PBL in all examine group are perforin positive (total perforin is significantly lower than in control group). Surprisingly, percentages of double positive cells showed significant decrease in all examine lymphocyte subpopulations (CD3+ P+, CD4+P+, CD8+P+, CD16+P+ and CD56+P+ cells) compared to controls. These results suggest that human perforin is differentially expressed in distinct sub-populations of peripheral blood lymphocytes of patients with lung carcinoma, implicating the important role of perforin positive cells in na&iuml ; ve immune response and cytotoxic activity of peripheral blood lymphocytes.

lung carcinoma; cellular immunity; perforin; NKT cells

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Podaci o prilogu

2007.

objavljeno

Podaci o matičnoj publikaciji

5th Central European Oncology Congress

Podaci o skupu

5th Central European Oncology Congress, CEOC 2007

poster

20.06.2007-23.06.2007

Opatija, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti