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Nasal powder drug delivery

Nasal dry powder formulations ; Benefits associated with nasal powder drug delivery Residence time in the nasal cavity, drug concentration at the absorption site, formulation stability ; Drug powder or drug/polymer powder formulation for nasal drug delivery? Drug solubility, absorption, irritability, drug carrier (polymer) ; Powder properties affecting nasal deposition and drug delivery ; Deposition pattern, aerodynamic properties, particle distribution in the nose, particle size, shape, density, flow Polymers in nasal powder delivery system Hydrophilic polymers, functional groups, polymer molecular weight, cross-linking density, swelling ability, transport enhancing effect, bioadhesive properties, new generation mucoadhesive polymers Microspheres as nasal drug delivery devices Drug delivery system, microspheres, polymeric composition, polymer-drug interaction, mucociliary clearance, nasal absorption, bioavailability ; Preparation methods Spray-drying method, emulsification method, emulsion polymerization technique ; Microsphere characterization ; Particle size, morphology, drug content, swelling properties, bioadhesion, drug release profile ; Chitosan formulated spray-dried microspheres ; Chitosan molecular weight, conventional microspheres, composed microspheres, spray-drying parameters, particle size analysis, encapsulation efficiency, physical state of the drug, zeta-potential, tensile studies, swelling studies, in vitro drug release Toxicological considerations Local irritation, tissue damage, epithelial toxicity, ciliotoxicity, mucus turnover, reversible effects

Nasal powder, Drug delivery, Formulation, Polymers, Microspheres, Chitosan, Toxicological considerations

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