engleski

THE ROLE OF NKT AND REGULATORY T (Tregs) CELLS IN CONTROL OF COLORECTAL TUMOR GROWTH ON SYSTEMIC AND LOCAL LEVEL

NKT cells are a subset of T cells that share properties of natural killer cells and conventional T cells. They are involved in innate immune responses, tumor rejection, post transplantation immunotherapy, immune surveillance and control of autoimmune diseases, as well as, in a number of pathological conditions, and have been shown to regulate viral infections in vivo, and control tumor growth. They may also play both protective and harmful roles in the progression of certain autoimmune diseases, such as diabetes, lupus, atherosclerosis, and allergen-induced asthma. NK cells and cytotoxic T lymphocytes can use the perforin/granzyme pathway to kill virally infected cells, as well as tumor cells. Dysregulation of this pathway can be associated with the appearance of many serious diseases. The aim of this study was to investigate the characteristics of human regulatory T and NKT cell, using a flow cytometric technique (FACSCalibur) for detecting phenotype of isolating human peripheral blood lymphocytes (PBL), as well as the lymphocytes from the irrigating areas of lower mesenteric vein, of patients with colorectal carcinoma on systemic and local levels, comparing to healthy volunteers. Our findings suggest that the patients with colorectal carcinoma have significantly increased percentage of NKT and Treg cells, especially on local level, which may interplay with the function of innate immune response during tumor development and their values might be used as a predictor marker.

NKT cells; Tregs; colorectal carcinoma; innate immunity

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