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Honey bee products and their polyphenolic compounds in treatment of diabetes

Free radicals have been implicated in playing a role in over 100 diseases, including cancer, atherosclerosis, rheumatoid arthritis, inflamatory bowel disease, diabetes, asthma, cardiovascular disease, liver disease, macular degeneration, cataract, periodontal disease and other inflammatory processes. There is growing recognition that many polyphenolic compounds presents in most plants and bee products such as honey, propolis and pollen, may have beneficial effect on human health. Epidemiological, clinical, and laboratory research of bee products, phytochemicals and their flavonoids and other antioxidants suggest their use in the prevention and treatment of number of diseases, including diabetes. This paper reviews the relationship of connections between flavonoids present in bee products and plants and diabetes/obesity based on various in vivo and in vitro studies. It also describes current understandings of the possible mechanisms of influence of flavonoids and multiple beneficial effects in combating diabetes and diabetes-related complications. Taken together, this information provides a basis for multimodal therapeutic effects of bee products, plants and related flavonoids on diabetes. Finally, this article presents an overview of various aspect of the pathobiology of diabetes mellitus and an ability of molecular approach in treatment of it.

diabetes mellitus, bee products, flavonoids, polyphenolic components, phytochemicals

SERIES ISBN:0-9656038-5-7 Knjiga se objavljuje i kao serija publikacija citiranih u Bio-science Information Service of Biological Abstracts, Current Awareness in Biological Sciences, CAB Journals, Current Contents, International Literary Information Centre in Science and Extension, INSDOC etc