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Improved antitumor effect by combined treatment of propolis and chemotherapeutic drugs (CROSBI ID 537746)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Oršolić, Nada ; Horvat Knežević, Atika ; Benković, Vesna ; Bašić, Ivan Improved antitumor effect by combined treatment of propolis and chemotherapeutic drugs // Apimondia, 2007. 2007

Podaci o odgovornosti

Oršolić, Nada ; Horvat Knežević, Atika ; Benković, Vesna ; Bašić, Ivan

engleski

Improved antitumor effect by combined treatment of propolis and chemotherapeutic drugs

Using a Swiss albino mouse model of Ehrlich ascites tumor (EAT), we investigated antitumor efficacy of two preparations of propolis (water and ethanolic extract) or quercetin, a compound of propolis, combined with chemotherapeutic drugs (Cisplatin and Doxorubicin). Egzamination was directed to suppression of tumor progression expressed as the percent increased life span. Propolis or quercetin were administrated ip to animals at doses of 50 mg kg-1 body weight for three consecutive days before tumor inoculation. Doxorubicin (20 mg kg-1) or cisplatin (10 mg kg-1) were given to mice two days after tumor cell inoculation. The results of log rank test between treated and control mice showed:WSDP, p=0.00291 ; WSDP + CIS, p=0.00781 ; WSDP + DOX, p=0.4998 ; EEP, p=0.00902 ; EEP + CIS, p=0.27603 ; EEP + DOX, p=0.22014 ; QU, p=0.27454 ; QU + CIS, p=0.72713 ; QU + DOX, p= 0.02667 ; CIS, p=0.00350 ; DOX, p= 0.2593. Combined treatment with test compounds and Cisplatin resulted in pozitive outcome (p=0, 00853 ; p=0, 00767 ; p=0, 02500) versus cisplatin alone, however combined treatment with doxorubicin was ineffective. Our findings indicate that WSDP, EEP, and quercetin significantly enhanced the antiproliferative and cytotoxic action of cisplatin and that propolis compounds may be usefully used for lowering the toxicity and other deteriorating activities chemotherapeutic drugs.

chemotherapeutic drugs; propolis preparations; flavonoids; tumor; toxicity

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Podaci o prilogu

2007.

objavljeno

Podaci o matičnoj publikaciji

Apimondia, 2007

Podaci o skupu

International Apicultural Congress, Melbourne, Australia

predavanje

09.09.2007-14.09.2007

Melbourne, Australija

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biologija