Population genetic studies of HLA-G - allele frequencies and linkage disequilibrium with HLA-A1 (CROSBI ID 85329)
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Podaci o odgovornosti
Ober, C. ; Rosinsky, B. ; Grimsley, C. ; van der Ven, Katrin ; Robertson, A. ; Runge, A.
engleski
Population genetic studies of HLA-G - allele frequencies and linkage disequilibrium with HLA-A1
HLA-G is a class I gene that is expressed in the extravillous cytotrophoblast. Although the function of this gene is still unknown, its expression at the maternal-fetal interface suggests that HLA-G may play a key role in the induction of tolerance during pregnancy. Preliminary to our studies of the effects of HLA-G polymorphisms on pregnancy outcome, we have defined HLA-G alleles in the Hutterites. We report here the presence of nine HLA-G alleles that differ with respect to nucleotide sequences, including four groups of alleles that differ with respect to amino acid sequences, and striking linkage disequilibrium between HLA-G and HLA-A alleles. The levels and sites of polymorphism in HLA-G suggest that this gene had a unique evolutionary history and may perform nonclassical functions at the maternal-fetal interface.
HLA-G ; allele frequencies ; HLA-A1
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Podaci o izdanju
32 (2)
1996.
111-123
objavljeno
0165-0378
10.1016/s0165-0378(96)01000-5
Povezanost rada
Kliničke medicinske znanosti