engleski

Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis

To explore the balance between serum and synovial fluid levels of interleukin (IL)-10 and IL-18 in children with juvenile idiopathic arthritis (JIA). Blood samples were obtained from 81 children with JIA and 18 control children. Synovial fluid samples were collected from 16 children with pauciarticular JIA. Concentrations of IL-10 and IL-18 were determined using commercial kits. Patients with systemic JIA had higher serum levels of IL-18 than patients with other forms of JIA or control children, both during the active (median, range: 6240, 1600 – 78750 pg/mL) and inactive (1615, 513 – 3270 pg/mL) phase of disease (ANOVA, p < 0.05). Levels of IL-18 in sera of children with pauciarticular JIA (255, 89 – 4342 pg/mL) were similar to the corresponding synovial fluid levels (217, 89 – 1245 pg/mL). Clinical remission was characterised by higher serum levels of IL-10 in children with systemic JIA (ANOVA, p < 0.05 vs. the other groups) while the differences during the active phase were not significant. Moreover, synovial levels of IL-10 in patients with pauciarticular JIA (20.8, 1.6 – 67.6 pg/mL) were higher than serum levels of IL-10 in the same patients (3.0, 0.0 – 32.7 pg/mL) (t-test, p < 0.05). As IL-18 appears to be an important mediator of systemic JIA, its inhibition might be a base for a successful therapeutic approach. Role of IL-10 in pathogenesis of JIA is less clear, but it seems to be predominantly involved in local, rather than systemic pathogenetic processes.

arthritis juvenile; interleukin-10; interleukin-18

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