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Statins and angiotensin-converting enzyme inhibitors can delay the onset of arteriosclerosis (CROSBI ID 539181)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Ljubić, S ; Božikov, J ; Pavlić-Renar, I ; Metelko, Ž Statins and angiotensin-converting enzyme inhibitors can delay the onset of arteriosclerosis // Diabetic medicine. 2006. str. 671-671

Podaci o odgovornosti

Ljubić, S ; Božikov, J ; Pavlić-Renar, I ; Metelko, Ž

engleski

Statins and angiotensin-converting enzyme inhibitors can delay the onset of arteriosclerosis

Aim: The aim of the study was to investigate the role of statin, aspirin and angiotensin-converting enzyme (ACE) inhibitor therapy in the development of atherosclerosis via their effect on the reduction in C-reactive protein (CRP) and homocysteine (HCY). Methods: A total of 243 type 2 diabetic patients were studied during a 1-year follow-up period. Patients were randomized to receive atorvastatin (n = 59), simvastatin (n = 64), pravastatin (n = 38), or ACEinhibitor lisinopril (n = 43). The control group included 39 patients. CRP, HCY, atherogenic index of plasma (AIP), body mass index (BMI), pulse pressure (PP) and albumin excretion rate (AER) were determined. The patients were assigned to groups based on AER/mg/24 h/ (<30, 30&#8211; 300, >300), PP (<45, 45&#8211; 50, 50&#8211; 65, >65) and BMI (<25, 25&#8211; 30, >30). Results: ANOVA revealed significant differences in initial CRP and AIP (P = 0.01 and P = 0.041, respectively) according to AER and BMI (both P < 0.001), and in HCY and AIP (both P < 0.001) according to PP. Multiple linear regression for CRP, HCY, age, diabetes duration, BMI, AIP, AER and PP was significant (P < 0.01) and showed BMI and AIP to be independent predictors of CRP, and age, AER and BMI independent predictors of HCY (P < 0.05). CRP was significantly reduced in the groups treated with atorvastatin (P < 0.001), simvastatin (P = 0.049) and lisinopril (P = 0.012). HCY was significantly reduced in the simvastatinand pravastatin-treated groups (P = 0.015 vs. P = 0.002), and AIP and PP were significantly reduced in the simvastatin- and atorvastatin-treated groups (both P < 0.01). A significant reduction (P < 0.005) in AER and PP was revealed in the lisinopril group. Conclusions: BMI was an independent predictor of inflammatory markers, whereas ACE-inhibitors and statins had a beneficial effect on blood pressure and lipid profile. The latter can attenuate inflammation by reducing CRP and HCY and, consequently, together with body weight reduction, delay the development of atherosclerosis.

statins; ACE-inhibitors; BMI; atherosclerosis

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Podaci o prilogu

671-671.

2006.

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objavljeno

Podaci o matičnoj publikaciji

Diabetic medicine

0742-3071

Podaci o skupu

19th World Diabetes Congress

poster

03.12.2006-07.12.2006

Cape Town, Južnoafrička Republika

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost