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Bone metabolism in mares during late pregnancy and early lactation (CROSBI ID 539583)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Filipović, Natalija ; Stojević, Zvonko ; Prvanović, Nikica ; Tuček, Zvonimir ; Kušec, Vesna ; Beer Ljubić, Blanka Bone metabolism in mares during late pregnancy and early lactation // Calcified tissue international / Civitelli, Roberto ; Ralston, Stuart H. (ur.). 2008. str. S153-S153

Podaci o odgovornosti

Filipović, Natalija ; Stojević, Zvonko ; Prvanović, Nikica ; Tuček, Zvonimir ; Kušec, Vesna ; Beer Ljubić, Blanka

engleski

Bone metabolism in mares during late pregnancy and early lactation

In the present study, the changes in the blood serum parathyroid hormone (PTH), total calcium (Ca), inorganic phosphorus (P), carboxy-terminal telopeptide of type I collagen (CTx), and estradiol (E) concentrations and the bone specific alkaline phosphatase (BALP) activity in mares were investigated with the aim of examining the influence of late pregnancy and lactation on bone metabolism parameters in mares. The research was conducted on mares of Croatian cold-blood horse breed (n = 13), between 3 and 18 years of age. Samples were taken 60± ; ; 10 days and 20± ; ; 10 days before foaling, and 20± ; ; 10 days and 60± ; ; 10 days after foaling (1st, 2nd, 3rd and 4th period, respectively). Significant changes in the concentration of Ca (F=5.26, p<0.005), P (F=7.18, p<0.001), E (F=50.17, p<0.0001) and in the activity of BALP (F=3.27, p<0.05) were observed. Significant changes in the concentration of CTx and PTH were not established. Ca was higher in the 3rd (p<0.05) and 4th (p<0.01) in comparison with the 1st period. P was higher in the 3rd in comparison with the 1st and 2nd period (p<0.01). The activity of BALP was higher in the 4th in comparison with the 1st period (p<0.05). E was lower in the 2nd, 3rd and 4th in comparison with the 1st period, and in the 3rd and 4th in comparison with the 2nd period (p<0.0005). A positive correlation between Ca and P (r=0.42, p<0.005), and between Ca and BALP (r=0.55, p<0.0001) and P and BALP (r=0.29, p<0.05) was found. A negative correlation between E and Ca (r=-0.61, p<0.0001), E and P (r=-0.49, p<0.001), E and BALP (r=-0.46, p<0.005), age and P (r=-0.41, p<0.005) and age and BALP (r=-0.30, p<0.05) was found. Low concentrations of Ca in the 1st period show that demands for minerals in mares were the greatest in late pregnancy, during the fastest growth and mineralization of the foetal skeleton. The lowest activity of BALP in the same period shows that those demands were, at least partially, satisfied by decreased bone synthesis, while bone resorption was not elevated. A negative correlation between E and Ca, P and BALP are in agreement with the known effects of estrogens on decreased bone remodelling. A negative correlation between BALP and age could indicate a decrease in osteoblast activity in older mares.

bone metabolism; mares; pregnancy; lactation

doi: 10.1007/s00223-008-9118-5

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

S153-S153.

2008.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Calcified tissue international

Civitelli, Roberto ; Ralston, Stuart H.

New York (NY): Springer

0171-967X

Podaci o skupu

European Symposium on Calcified Tissues (35 ; 2008)

poster

24.05.2008-28.05.2008

Barcelona, Španjolska

Povezanost rada

Veterinarska medicina

Indeksiranost