engleski

Postoperative nausea and vomiting are independent of oculocardiac reflex in strabismus surgery in children anesthetized with halothane and nitrous oxide.

Background and Goal of the Study: Postoperative nausea and vomiting (PONV) appear during squint surgery. The data are still controversial about interdependence of PONV and oculocardiac reflex (OCR). As was proved in the recent study, rocuronium attenuates OCR. If these occurrences are dependent, rocuronium is expected to diminish PONV. The goal of this study was to test the possibility of diminishing PONV with 0.4 mg/kg-1 of rocuronium to prove their interdependence. Materials and Methods: ASA 1 children, 8 through 10 years old (6, 9-10 ; median, range), undergoing surgery of the medial rectus muscle (MRM) were randomly assigned to two groups. In the R group (n=59), 0.4 mg/kg-1 of rocuronium was administered intravenously before intubation. In the C group (n=60), no muscle relaxant was used. The anesthesia was induced and maintained with halothane and N2O/O2 (50/60%). We registered nausea, vomiting and emetic episodes during 0-6, 7-12 and 13-24 h, postoperatively. Nausea was defined as unpleasant sensation with urge to vomit, and vomiting as forceful expulsion of gastric content. Chi-square, and t-test were used for statistical analysis ; p<0.05 was considered statistically significant. Results and Discussion: There was no difference between groups regarding gender (p=0.77), age (p=0.17), body mass (p=0.77), ET halothane (p=0.72), or duration of surgery (p=0.75), and anesthesia (p=0.67). There was significant difference between groups regarding occurrence of OCR (p=0.08). Despite rocuronium attenuation of OCR, the occurrence of PONV was not diminished. There were no differences regarding PONV periods among children in two groups. Conclusions: Rocuronium (0.4 mg/kg-1) does not diminish the appearance of PONV. We could not find association between OCR and PONV during squint surgery in children anesthetized with halothane and nitrous oxide.

oculocardiac reflex; anesthesia; postoperative nausea

nije evidentirano