engleski

Lipid levels in female patients with affective disorders

The role of the serum lipids (total cholesterol, high-density lipoprotein cholesterol /HDL-C/, low-density lipoprotein cholesterol /LDL-C/, triglycerides /TG/) in the pathophysiology of the mood disorders is not clear. The aim of this study was to determine lipid profile in patients with affective disorders. The study included medication free female subjects: 41 patients with bipolar disorder (22 in a manic and 19 in a depressive phase), 34 patients with major depression and 50 healthy controls. Serum lipids levels were determined using standard laboratory tests. All patients had significantly lower HDL-C values than control subjects. Increased TG levels were found in patients with bipolar disorder compared to healthy subjects. The changes in lipids profiles persisted when data were adjusted for age, smoking and menopause. The results revealed no differences in the cholestrol and LDL-C levels and body mass index, but significant differences in the ratios of cholesterol/HDL-C and LDL-C/HDL-C values (atherogenic index) among groups. Our results suggest that low HDL-C levels and high atherogenic index might be a hallmark of affective disorders. Since low HDL-C levels could be a risk factor for the development of coronary heart disease, further investigation of the lipids metabolism in affective disorders is warranted.

Major depressive disorder ; Bipolar disorder ; mania ; Cholesterol ; High-density-lipoprotein cholesterol ; Low-density-lipoprotein cholesterol ; Triglycerides

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