High macrolide resistance of nasopharyngeal isolates of Streptococcus pneumoniae in children from Zagreb region (CROSBI ID 540761)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Vraneš, Jasmina ; Senji, Peter ; Anušić, Maja ; Jarža-Davila, Neda ; Bedenić, Branka ; Knežević, Jasna ; Marijan, Tatjana ; Leskovar, Vladimira
engleski
High macrolide resistance of nasopharyngeal isolates of Streptococcus pneumoniae in children from Zagreb region
Background and aims: It is well known that monitoring of antimicrobial resistance of nasopharyngeal strains of Streptococcus pneumoniae is an excellent approach for prediction of resistance in clinical isolates. The aim of this study was to determine the susceptibility of nasopharyngeal isolates of S. pneumoniae to antimicrobial agents. Methods: Nasopharyngeal swabs were collected from 634 children aged 1-15 (the median age was 3 years) in two-month period (October-November, 2007). After cultivation and identification of S. pneumoniae, 93 strains were tested by a broth microdilution method, and minimal inhibitory concentrations (MICs) was determined for penicillin G, amoxicillin, ceftriaxone, cefuroxime, meropenem, erythromycin, azithromycin and clarithromycin. Results: The resistance to penicillin was determined in 31 (33.3%) strains with a 12.9% of highly resistant S. pneumoniae isolates. The resistance to other beta-lactams was lower with less than 10% of non-susceptibility to ceftriaxone and only 6.4% isolates intermediately resistant to amoxicillin. Macrolides showed decreased activity against tested strains, with resistance being 38.7%, 36.6% and 33.3% for erythromycin, azithromycin and clarithromycin, respectively. MIC90 of azithromycin and clarithromycin was 512 mg/L, while MIC90 of erythromycin was 1024 mg/L. Conclusions: Amoxicillin showed the best in vitro activity among tested antibiotics, and thus might be considered as a drug of choice for the therapy of infections of possible pneumococcal etiology in children. The high macrolide resistance observed compromise clinical utility of these antibiotics and might be explained by extensive out-patient use of azithromycin in Croatia.
Streptococcus pneumoniae; resistance; macrolide
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Podaci o prilogu
2008.
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objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
26th Annual Meeting of the European Society for Paediatric Infectious Diseases
poster
13.05.2008-17.05.2008
Graz, Austrija