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izvor podataka: crosbi

Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients (CROSBI ID 144078)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Stipčević, Tamara ; Kusačić-Kuna, Sanja ; Deželjin, Martina ; Dodig, Damir ; Koršić, Mirko ; Pivac, Nela ; Muck-Šeler, Dorotea Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients // Hormone research, 71 (2009), 4; 207-212. doi: 10.1159/000201109

Podaci o odgovornosti

Stipčević, Tamara ; Kusačić-Kuna, Sanja ; Deželjin, Martina ; Dodig, Damir ; Koršić, Mirko ; Pivac, Nela ; Muck-Šeler, Dorotea

engleski

Platelet serotonin concentration and monoamine oxidase activity in hypothyroid patients

The relationship between hypothalamic-pituitary-thyroid (HPT) axis and serotonergic (5-HT) system is not clear. The aim of the study was to determine platelet biochemical markers (5-HT concentration and monoamine oxidase /MAO-B/ activity) in hypothyroid patients. The study included 25 female medication-free hypothyroid patients in postoperative follow-up after total thyroidectomy due to papillary thyroid carcinoma, who were not treated with synthetic thyroxine (T4) for 4 weeks, and 44 age matched euthyroid healthy women. Platelet 5-HT concentration, platelet MAO-B activity, total T4 and thyroid stimulating hormone (TSH) levels were determined using spectrofluorimetric methods, radioimmunoassay and fluoroimmunoassay, respectively. Hypothyroid patients had significantly higher TSH, significantly lower T4 levels and platelet 5-HT concentration, and unchanged platelet MAO-B acrivity than healthy subjects. A positive correlation between 5-HT concentration and platelet MAO-B activity, and between platelet MAO-B activity and T4 in control subjects was found. Reduced platelet 5-HT concentrations in hypothyroid patients suggests a complex interaction between 5-HT system and HPT axis activity, which could be related to frequent occurrence of depressive symptoms in hypothyroid patients. The determination of platelet 5-HT concentration should be considered as a diagnostic tool for the evaluation of depressive symptoms in hypothyroid patients during hormone withdrawal procedure.

Platelet 5-HT ; Platelet MAO B ; hypothyroidism ; thyroxine ; thyroid stimulating hormone

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Podaci o izdanju

71 (4)

2009.

207-212

objavljeno

0301-0163

1423-0046

10.1159/000201109

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Poveznice
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