Genomic instability of the APC gene found in glioblastoma (CROSBI ID 541461)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Beroš, Vili ; Pećina-Šlaus, Nives ; Houra, Karlo ; Nikuševa-Martić, Tamara
engleski
Genomic instability of the APC gene found in glioblastoma
The etiology and pathogenesis of tumors of the central nervous system are still inadequately explained. This study analyses tumor suppressor gene— adenomatous polyposis coli (APC) in 28 patients with glioblastoma. Glioblastoma samples were tested for gene instability by PCR/loss of heterozygosity using RFLP method. Two polymorphic markers were used: an Rsa I polymorphic site in exon 11, and an Msp I polymorphic site in exon 15. The results of our analysis for both markers showed allelic loss of the APC gene in 40% of our sample out of 25 heterozygous patients (informativeness 89%). Another 20% of samples demonstrated allelic imbalance of the APC allele in tumor tissue. Altogether, there were 15 samples (60%) demonstrating instability of this tumor suppressor gene. Despite increasing knowledge on glioma biology and genetics, the prognostic tools for glioblastoma still need improvement.
gen APC; glioblastom
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Podaci o prilogu
47-47.
2008.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Neurologia Croatica. Supplement
1331-5196
Podaci o skupu
5th Congress of the Croatian Neurosurgical Society (5 ; 2008) ; Congress of Neurological Surgeons
predavanje
02.09.2008-05.09.2008
Dubrovnik, Hrvatska