Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening (CROSBI ID 144705)
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Podaci o odgovornosti
Hasnaoui-Dijoux, Ghannia ; Majerić Elenkov, Maja ; Lutje Spelberg, Jeffrey H. ; Hauer, Bernhard ; Janssen, B. Dick
engleski
Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening
Halohydrin dehalogenase is a highly promiscuous enzyme that can catalyze enantioselective epoxide ring opening with at least nine different anionic nucleophiles. Its capacity to form carbon-nitrogen, carbon-oxygen, carbon-sulfur, and carbon-carbon bonds makes it possible to use this enzyme for the preparation of a range of highly enantioenriched beta-substituted alcohols or derivatives thereof, including cyanoalcohols, nitroalcohols, and oxazolidinones.
Biocatalysis; Enantioselectivity; Epoxides; Halohydrin dehalogenase; Nucleophiles
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Podaci o izdanju
9 (7)
2008.
1048-1051
objavljeno
1439-4227
10.1002/cbic.200700734