engleski

Gastric cancer and H. pylori infection in Croatia: is CagA status carcinogenic marker?

The purpose of the study: In serological studies, the relation between H. pylori (Hp) infection with CagA(+) strains and development of gastric cancer (GC) is controversial in some countries. In this study we investigated the prevalence of Hp infection and CagA seropositivity in a group of patients with and without GC to determine whether infection with Hp/CagA(+) strains is linked to development of GC. Patients and Methods: 20 patients with GC (12M:8F, mean age = 62 yr., range = 45-90), 24 patients with gastric ulcer (GU) (10M:14F, mean age = 65 yr., range = 44-80), and 33 patients with duodenal ulcer (DU) (15M:18F, mean age = 47 yr., range = 24-73). Hp status was determined with histology, urease, serology (CF, ELISA), and CagA seropositivity was assessed by the presence of CagA IgG antibodies using ELISA (Eurospital, Trieste, Italy). Results: Table shows the prevalence of CagA antibodies in the three groups of patients: Group Age of patients (yr) Total <50 50-59 >60 GC 1/2 3/4 13/14 17/20 (85,0%) GU 2/3 1/1 12/19 15/24 (62,5%) DU 19/19 7/8 5/6 31/33 (93,9%) CagA seropositivity was found in more Hp(+) DU than GU patients, 31 (93,9%) vs. 15 (62,5%); significant difference P<0,05. However CagA seropositivity was found in more Hp(+) GC than GU patients, 17 (85,0%) vs.15 (62,5%); no significant difference P>0,05. Conclusions: Hp infection is a risk for GC, but the presence of CagA strain is not the critical factor for the development of GC.

Helicobacter pylori; gastric cancer; CagA(+) strains; serology; ELISA; CF test; CagA IgG antibodies

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