engleski

Serum Dipeptidyl Peptidase IV (DPP IV/CD26) Activity in Patients With Inflammatory Bowel Diseases – A New Diagnostic Marker?

The dipeptidyl peptidase IV (DPP IV/CD26) is a membrane-bound glycoprotein with unique multifunctional properties. Soluble DPP IV is also present in the serum and other biological fluids. The cleavage by DPP IV can result in significant change in the activity of physiological peptides. The aim of this study was to evaluate the clinical relevance of changes in serum DPP IV/CD26 activity in adult patients with inflammatory bowel diseases (IBD: Crohn&#8217; s disease, CD and ulcerative colitis, UC). We hypothesized that changes in DPP IV serum activity could relate to the disease activity. Furthermore, we wanted to estimate if the serum DPP IV activity could be a potential distinguishing marker between CD and UC. The study was performed on 62 patients, 38 with CD, and 24 with UC. The diagnoses of CD or UC were established on the basis of clinical history, laboratory, endoscopic and histological data. The control group included 65 healthy donors. Serum DPP IV/CD26 activity has been measured spectrofotometrically. Enzyme activities are expressed as international unit per liter of serum (U/L). Both serum DPP IV activities in patients with CD (36, 83 &plusmn ; ; 9, 74 U/L) and UC (33, 87 &plusmn ; ; 10, 69 U/L) were statistically significantly decreased compared with the levels in healthy controls (48, 37 &plusmn ; ; 8, 94 U/L), (p<0, 001). Values correlated inversely with the disease severity for both diseases. No statistically significant difference in the serum DPP IV activity in patients with CD and UC was found. The results of this study sustained the statement that DPP IV/CD26 could be involved in the pathophysiology of IBD. Serum DPP IV activity appears to be useful as an available, non-invasive marker in the diagnosis of the disease activity. On the other hand, the results indicated that the serum DPP IV activity could not be a good marker for differential diagnosis between CD and UC.

Dipeptidyl Peptidase IV; CD26 molecule; inflammatory bowel diseases

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