Microwave Synthesis and Spectroscopic Study of 3-Quinoline-substituted alpha-Aminophosphonates (CROSBI ID 541841)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Juribašić, Marina ; Stella, Laura ; Marinić, Željko ; Vinković, Marijana ; Tušek-Božić, Ljerka
engleski
Microwave Synthesis and Spectroscopic Study of 3-Quinoline-substituted alpha-Aminophosphonates
The synthesis of alpha-aminophosphonate derivatives has attracted current interest in the organic and medicinal chemistry due to important biological and pharmacological properties of these organophosphorus compounds.[1] Another interesting aspect regarding this kind of compounds arises from their ability of forming various types of transition metal complexes, which might also be of interest owing to their biological activity.[2] The classical Kabachnik-Fields reaction, a three-component one-pot reaction of amine, carbonyl compound (aldehyde or ketone) and hydrophosphoryl compound, has proven its great synthetic potential and significance as one of the simplest approaches to alpha-aminophosphonates.[3] We have directed out attention to investigations on the course of microwave-assisted one-pot three-component reaction of quinoline-3-carboxaldehyde and aniline (Scheme 1) as well as 3-aminoquinoline and benzaldehyde (Scheme 2), respectively, with diethyl phosphite. Here, we present 1H and 31P NMR, MS and IR spectroscopic characterization of unusual monoester phosphonate derivatives (2, 3, 5) isolated along with diethyl phosphonates (1, 4).
aminophosphonate; NMR; IR spectroscopy; ESI MS
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Podaci o prilogu
66-66.
2008.
objavljeno
Podaci o matičnoj publikaciji
EUCMOS 2008, Book of Abstracts
Musić, S ; Ristić, M ; Krehula, S
Zagreb: Institut Ruđer Bošković
978-953-6690-76-3
Podaci o skupu
EUCMOS 2008 XXIX European Congress on Molecular Spectroscopy
poster
31.08.2008-05.09.2008
Opatija, Hrvatska