engleski

A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives

The conformational behaviour of NSAID series (ibuprofen, fenprofen, ketoprofen, diclophenac and indomethacin) monohydroxamic acids and their intermediates have been studied in DMSO-d6 solution by one- and two-dimesional homo and heteronuclear 1H and 13C NMR spectroscopy and in solid state using FTIR spectroscopy. Significant hydrogen bonding effects were observed in both, solid state and solutions. The NMR spectra (1H and 13C NMR, COSY, NOESY, HMBC, HETCOR) revealed that investigated NSAID hydroxamic acids and their corresponding intermediates in DMSO solution are in keto form of cis-(Z) conformer with intramolecular hydrogen bond O-H...O= type. NMR findings observed in DMSO-d6 solution are in good agreement with FTIR of NSAID hydroxamic acids in solid state.

Hydrogen bond; NSAID hydroxamic acis; NMR spectroscopy; one- and two-dimensional homo and heteronuclear 1H and 13C NMR; IR spectroscopy

nije evidentirano