engleski

DNA repair in radiation resistant bacterium Deinococcus radiodurans

Deinococcus radiodurans, an extremophile bacterium, sustains extreme conditions of life, such as excessive desiccation and exposure to high doses of ionizing radiation. Both desiccation and radiation cause DNA double-strand breaks, the most severe form of genomic damage. Whereas most vegetative prokaryotic and eukaryotic cells can survive less than a dozen simultaneous double-strand DNA breaks, D. radiodurans survives extreme desiccation and ionizing radiation breaking its genome into hundreds of fragments. Remarkably, in just couple of hours, these fragments are reassembled into functional chromosomes due to an efficient and precise DNA repair process. We have found that genome reconstitution in D. radiodurans following gamma radiation involves a novel mechanism called "extended synthesis-dependent strand annealing", followed and completed by homologous recombination.

Deinococcus radiodurans; DNA repair; homologous recombination; radiation

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