engleski

Directing diarrheal disease research towards disease burden reduction

Despite gains in controlling mortality related to diarrheal disease the burden of disease remains unacceptably high. To refocus health research to target disease burden reduction as the goal of research in child health the Child Health and Nutrition Research Initiative developed a systematic strategy to rank health research options. This priority setting exercise included the listing of 46 competitive research options in diarrheal disease and their critical and quantitative appraisal by ten experts based on five criteria for research that reflects the ability of the research to be translated into interventions that achieved disease burden reduction. These criteria included the answerability of the research questions ; the efficacy and effectiveness of the intervention resulting from the research ; the maximal potential for disease burden reduction of the interventions derived from the research ; and the overall effect of the research derived intervention on equity. Experts scored each research option independently in order to delineate the best investments for diarrheal disease control in the developing world to reduce the burden of disease by 2015. Priority scores obtained for health policy and systems research obtained eight of the top ten rankings in overall scores indicating that current health research investments are significantly different from those estimated to be the most effective in reducing the global burden of diarrheal disease by the year 2015.

diarrheal disease; research priorities; child heath; diarrhoeal diseases; mortality; priority setting; medical research

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