Fenoprofen and ketoprofen amides as potential antitumor agents (CROSBI ID 145087)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Marjanović, Marko ; Zorc, Branka ; Pejnović, Lana ; Zovko, Marijana ; Kralj, Marijeta
engleski
Fenoprofen and ketoprofen amides as potential antitumor agents
Following numerous experimental observations that various non-steroidal anti-inflammatory drugs have antitumor potentials, a series of fenoprofenamides (1a– g) and ketoprofenamides (2a– c) was tested on proliferation of different human tumor cell lines and normal human fibroblasts in vitro. Fenoprofen and ketoprofen showed modest antiproliferative activity, whereas the growth inhibitory activity of the tested amides clearly demonstrates that the substituents linked by an amide bond are essential for the significantly stronger cytostatic activity, probably because of a greater lipophilicity and/or better cell uptake. Additionally, it was shown that the most active derivatives (1d and 2a) induced cell cycle arrest at the G1 phase, as well as apoptosis.
antiproliferative effect ; apoptosis ; cell cycle arrest ; fenoprofen ; fenoprofenamides ; human tumor cell lines ; ketoprofen ; ketoprofenamides ; lipophilicity
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Podaci o izdanju
69 (3)
2007.
222-226
objavljeno
1747-0277
1747-0285
10.1111/j.1747-0285.2007.00494.x
Povezanost rada
Biologija, Temeljne medicinske znanosti, Farmacija